Greg Scime help to found the Assisi Performing Arts Music Festival in 2001, an annual program emphasizing the study and performance of sacred music involving 40-50 musicians and choirs from the United States, Europe, South America, Asia, and Australia.  

His vision for founding the festival was to provide a unique experience for performers and students to become part of a welcoming and supportive community while making music, teaching, and performing in one of Umbria's most beautiful cities. 

Each Year, he directs the music for Sunday Mass at the Basilica of St. Francis in Assisi with the Festival Choir. His annual organ recital in Assisi is an annually celebrated event.